Jordan M. Sorokin
Research
Publications, preprints, and selected highlights
A selection of Jordan's peer-reviewed publications, preprints, and conference work — spanning circuit neuroscience and epilepsy, respiratory and arousal circuits, and machine-learning models for biology. Expand a highlight below for a short summary, or browse the full list further down.
Selected highlights
Bidirectional control of generalized epilepsy networks via rapid real-time switching of firing mode Neuron · Jan 2017
JM Sorokin, TJ Davidson, E Frechette, AM Abramian, K Deisseroth, JR Huguenard, JT Paz
Real-time, closed-loop optogenetic switching of thalamocortical firing modes to both initiate and abort absence seizures in freely behaving rodents — direct causal evidence that a single circuit motif controls seizure onset and termination.
Thalamic activity patterns unfolding over multiple time scales predict seizure onset in absence epilepsy bioRxiv · Mar 2020
JM Sorokin, A Williams, S Ganguli, JR Huguenard
Multi-timescale analysis of single-unit thalamic recordings revealing pre-ictal activity signatures that forecast the onset of absence seizures before they begin.
Breathing control center neurons that promote arousal in mice Science · Mar 2017
K Yackle, LA Schwarz, K Kam, JM Sorokin, JR Huguenard, JL Feldman, et al.
Identification of a molecularly defined subpopulation of breathing-center neurons that link respiratory rhythm to behavioral arousal — a mechanistic bridge between breathing and state of mind.
Effective Biological Representation Learning by Masking Gene Expression ICLR 2026 Workshop FM4Science
K Kenyon-Dean, A Selega, I Bendidi, JM Sorokin, L Bertinetto, D Errington, H Donnella, O Kraus
A self-supervised transcriptomics foundation model (TxFM) trained with a masked-gene-expression objective, together with DiverseRNA-1.4M, a curated corpus for learning general-purpose gene-expression representations.
All publications
Effective Biological Representation Learning by Masking Gene Expression
K Kenyon-Dean, A Selega, I Bendidi, JM Sorokin, L Bertinetto, D Errington, H Donnella, O Kraus
ICLR 2026 Workshop FM4Science · 2026 · arXiv:2605.31562
Self-supervised transcriptomics model (TxFM) and a curated training corpus, DiverseRNA-1.4M, for gene-expression representation learning.
Neuroimmune cortical organoids overexpressing C4A exhibit multiple schizophrenia endophenotypes
MM Stanton, S Modan, PM Taylor, HN Hariani, JM Sorokin, BG Rash, et al.
bioRxiv · Jan 2023 · bioRxiv
Optimization and scaling of patient-derived brain organoids uncovers deep phenotypes of disease
K Shah, R Bedi, A Rogozhnikov, P Ramkumar, Z Tong, B Rash, M Stanton, JM Sorokin, et al.
bioRxiv · Aug 2020 · bioRxiv
Thalamic activity patterns unfolding over multiple time scales predict seizure onset in absence epilepsy
JM Sorokin, A Williams, S Ganguli, JR Huguenard
bioRxiv · Mar 2020 · bioRxiv
Identification of unique pre-epileptic states via non-negative tensor decomposition of single unit recordings
JM Sorokin, S Ganguli
Computational and Systems Neuroscience (COSYNE) · Feb 2019
Abstract and poster, COSYNE 2019.
Breathing control center neurons that promote arousal in mice
K Yackle, LA Schwarz, K Kam, JM Sorokin, JR Huguenard, JL Feldman, et al.
Science · Mar 2017 · Science
Regulation of thalamic and cortical network synchrony by Scn8a
CD Makinson, BS Tanaka, JM Sorokin, JC Wong, CA Christian, AL Goldin, et al.
Neuron · Mar 2017 · Neuron
Bidirectional control of generalized epilepsy networks via rapid real-time switching of firing mode
JM Sorokin, TJ Davidson, E Frechette, AM Abramian, K Deisseroth, JR Huguenard, JT Paz
Neuron · Jan 2017 · Neuron
Real-time optogenetic switching of thalamocortical firing modes to initiate and abort absence seizures in freely behaving rodents.
Absence seizure susceptibility correlates with pre-ictal β oscillations
JM Sorokin, JT Paz, JR Huguenard
Journal of Physiology–Paris · Nov 2016 · Journal
Brain-wide maps of synaptic input to cortical interneurons
NR Wall, M De La Parra, JM Sorokin, H Taniguchi, ZJ Huang, et al.
Journal of Neuroscience · Apr 2016 · J Neurosci
Adverse functional effects of chemotherapy on whole-brain metabolism: a PET/CT quantitative analysis of FDG metabolic pattern of the "chemo-brain"
JM Sorokin, B Saboury, JHA Ahn, M Moghbel, S Basu, A Alavi
Clinical Nuclear Medicine · Jan 2014 · Journal